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CHOptimizer® - Optimized Media and Feed Strategy
The biopharmaceutical industry mainly uses mammalian cell cultures for the production of proteins as targets for human and animal diseases. As a result, new development processes are complex and highly challenging due to a number of factors.
CHOptimizer® Media Builder service is an advanced; Design of Experiments (DoE) approach to media optimization for CHO-based processes.
Designed for Performance and Flexibility
CHOptimizer® combines a modern, high-throughput approach with traditional ideas to deliver an optimized medium in a short timeline. It also includes field support and offers full access to the specific formula to ensure the ultimate in flexibility for the future.
Identify the Best Mix
24 blends from 4 base solutions
Identify Process Conditions
Pick 3-4 blends from DoE simulation
Identify 2-3 replicates, investigate temperature, pH, etc.
Perfom spent media analysis
Identify Feed Strategy
Optimize process | feed strategy
Determine final solution with feed
Build feeds based on spent media analysis
Test different feeds and feeding strategies
Custom optimized media
- ~10 days of work performed by application specialists
- Media supplies including optimized media and feed
- DoE software analytics
- Spent media analysis (96 tests)
- ambr® 15 and consumables
Benefit from Fully Optimized Media
Optimizing your media and feeds leveraging the experience and expertise of Lonza Sartorius will, in addition to increase titers, permit to increase your process and cell know-how. Our media development experts will guide you.
Complete Services for Your Media Development
Our media optimization toolbox will bring you a systemic approach for the difference phases of your product development. From benchmarking off the shelf solution for fast media selection, fully outsourced media optimization service and CHOptimizer® Media Builder service to bring you custom optimized media for your specific needs.
ambr® 15 fermentation is an automated microscale bioreactor system designed for microbial applications...
4 base solutions resulting from more than 50 years of experience and know-how in media development,...